Elements of Comet 1905 II

Dmd059121 1890..1905

Subcutaneous injection is an important route of administration for therapeutic proteins that provides several advantages over other modes of parenteral delivery. Despite extensive clinical use, the exact mechanism underlying subcutaneous absorption of proteins is not completely understood, and the accuracy of prediction of absorption of biotherapeutics in humans remains unsatisfactory. This rev...

Dmd065763 1905..1916

Montelukast has been recommended as a selective in vitro and in vivo probe of cytochrome P450 (P450) CYP2C8 activity, but its selectivity toward this enzyme remains unclear. We performed detailed characterization of montelukast metabolism in vitro using human liver microsomes (HLMs), expressed P450s, and uridine 59-diphospho-glucuronosyltransferases (UGTs). Kinetic and inhibition experiments pe...

Phoebus A. Levene, 1905

The Physics of Space and Time Ii: a Reassessment of Einstein's 1905 Special Relativity Paper

A detailed re-examination of the seminal paper on special relativity, taking into account recent work on the physical interpretation of the space-time Lorentz transformation as well as the modern understanding of classical electromagnetism as a certain limit of the fundamental underlying theory —quantum electrodynamics— is presented. Many errors both of physical principle and of a mathematical ...

Mark's Annual Reports, 1905